Diet supplement CoQ10 delays brain atrophy in aged transgenic mice with mutations in the amyloid precursor protein: An in vivo volume MRI study
Identifieur interne : 000E21 ( Main/Exploration ); précédent : 000E20; suivant : 000E22Diet supplement CoQ10 delays brain atrophy in aged transgenic mice with mutations in the amyloid precursor protein: An in vivo volume MRI study
Auteurs : Li [République populaire de Chine] ; Clifford R. Jack [États-Unis] ; Xi-Fei Yang [République populaire de Chine] ; Edward S. Yang [République populaire de Chine]Source :
- BioFactors [ 0951-6433 ] ; 2008.
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Abstract
We tested the hypotheses that supplemental intake of the diet supplement Coenzyme Q10 (CoQ10) could delay brain atrophy in double transgenic amyloid precursor protein (APP) / presenilin 1 (PS1), single transgenic APP and PS1 as well as wild type mice by volume MR image in vivo. One hundred and twelve mice (28 APP/PS1, 28 APP, 28 PS1 and 28 wild types) were studied. Half of each genotype group (n = 14 per group) was treated with CoQ10 2400 mg/kg/day, and the other half with placebo for 60 days. Magnetic resonance (MR) images were used to obtain the volumes of the hemispheres and hippocampi. APP / PS1, APP, PS1 and wild type mice treated with CoQ10 exhibited significantly less atrophy in hemisphere and hippocampus than those receiving placebo. The neuro‐protective effect of the CoQ10 on hemispheric volume, and hippocampal volume was related to genotype; greater in APP/PS1 than APP and PS1 mice and less in wild type mice. Our result indicated that CoQ10 may have therapeutic potential in the prevention and treatment of MCI and AD.
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DOI: 10.1002/biof.5520320120
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Yang</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:01DF26D10B0055A77F7430C325DD96A5FEC3D660</idno><date when="2008" year="2008">2008</date><idno type="doi">10.1002/biof.5520320120</idno><idno type="url">https://api.istex.fr/document/01DF26D10B0055A77F7430C325DD96A5FEC3D660/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">002073</idno><idno type="wicri:Area/Main/Curation">001D72</idno><idno type="wicri:Area/Main/Exploration">000E21</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Diet supplement CoQ10 delays brain atrophy in aged transgenic mice with mutations in the amyloid precursor protein: An in vivo volume MRI study</title><author><name sortKey="Li" sort="Li" uniqKey="Li" last="Li">Li</name><affiliation wicri:level="1"><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Hong Kong Applied Science and Technology Research Institute Company Limited, Hong Kong, HKSAR</wicri:regionArea><wicri:noRegion>HKSAR</wicri:noRegion></affiliation></author><author><name sortKey="Jack, Clifford R" sort="Jack, Clifford R" uniqKey="Jack C" first="Clifford R." last="Jack">Clifford R. Jack</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Radiology, Mayo Clinic and Foundation, Rochester, MN</wicri:regionArea><placeName><region type="state">Minnesota</region></placeName></affiliation></author><author><name sortKey="Yang, Xi Ei" sort="Yang, Xi Ei" uniqKey="Yang X" first="Xi-Fei" last="Yang">Xi-Fei Yang</name><affiliation wicri:level="1"><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Hong Kong Applied Science and Technology Research Institute Company Limited, Hong Kong, HKSAR</wicri:regionArea><wicri:noRegion>HKSAR</wicri:noRegion></affiliation></author><author><name sortKey="Yang, Edward S" sort="Yang, Edward S" uniqKey="Yang E" first="Edward S." last="Yang">Edward S. Yang</name><affiliation wicri:level="1"><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Hong Kong Applied Science and Technology Research Institute Company Limited, Hong Kong, HKSAR</wicri:regionArea><wicri:noRegion>HKSAR</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">BioFactors</title><title level="j" type="abbrev">BioFactors</title><idno type="ISSN">0951-6433</idno><idno type="eISSN">1872-8081</idno><imprint><publisher>IOS Press</publisher><pubPlace>Amsterdam</pubPlace><date type="published" when="2008">2008</date><biblScope unit="volume">32</biblScope><biblScope unit="issue">1‐4</biblScope><biblScope unit="page" from="169">169</biblScope><biblScope unit="page" to="178">178</biblScope></imprint><idno type="ISSN">0951-6433</idno></series><idno type="istex">01DF26D10B0055A77F7430C325DD96A5FEC3D660</idno><idno type="DOI">10.1002/biof.5520320120</idno><idno type="ArticleID">BIOF5520320120</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0951-6433</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>APP/PS1 double transgenic mice</term><term>Alzheimer's disease</term><term>antioxidant</term><term>hemispheric volume</term><term>hippocampal volume</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We tested the hypotheses that supplemental intake of the diet supplement Coenzyme Q10 (CoQ10) could delay brain atrophy in double transgenic amyloid precursor protein (APP) / presenilin 1 (PS1), single transgenic APP and PS1 as well as wild type mice by volume MR image in vivo. One hundred and twelve mice (28 APP/PS1, 28 APP, 28 PS1 and 28 wild types) were studied. Half of each genotype group (n = 14 per group) was treated with CoQ10 2400 mg/kg/day, and the other half with placebo for 60 days. Magnetic resonance (MR) images were used to obtain the volumes of the hemispheres and hippocampi. APP / PS1, APP, PS1 and wild type mice treated with CoQ10 exhibited significantly less atrophy in hemisphere and hippocampus than those receiving placebo. The neuro‐protective effect of the CoQ10 on hemispheric volume, and hippocampal volume was related to genotype; greater in APP/PS1 than APP and PS1 mice and less in wild type mice. Our result indicated that CoQ10 may have therapeutic potential in the prevention and treatment of MCI and AD.</div></front></TEI><affiliations><list><country><li>République populaire de Chine</li><li>États-Unis</li></country><region><li>Minnesota</li></region></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Li" sort="Li" uniqKey="Li" last="Li">Li</name></noRegion><name sortKey="Yang, Edward S" sort="Yang, Edward S" uniqKey="Yang E" first="Edward S." last="Yang">Edward S. Yang</name><name sortKey="Yang, Xi Ei" sort="Yang, Xi Ei" uniqKey="Yang X" first="Xi-Fei" last="Yang">Xi-Fei Yang</name></country><country name="États-Unis"><region name="Minnesota"><name sortKey="Jack, Clifford R" sort="Jack, Clifford R" uniqKey="Jack C" first="Clifford R." last="Jack">Clifford R. Jack</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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